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Papers

"Brain in White" by Dr. Greg Dunn.


Preprints (not yet peer reviewed)


5. Deo DR, Rezaii P, Hochberg LR,  Okamura AM, Shenoy KV*,  Henderson JM* (2020) Effects of peripheral haptic feedback on Intracortical brain-computer interface control and associated sensory responses in motor cortex. biorXiv. pdf url


4. Willett FR, Avansino DT, Hochberg LR, Henderson JM**, Shenoy KV** (2020) High-performance brain-to-text communication via imagined handwriting. biorXiv. pdf supp-mats.pdf supp-methods.pdf supp-video1.mp4 supp-video2.mp4 supp-video3.mp4 supp-video4.mp4 url


3. Wilson GH*, Stavisky SD*, Willett FR, Avansino DT, Kelemen JN, Hochberg LR, Henderson JM**, Druckmann S,** Shenoy KV** (2020) Decoding spoken English phonemes from intracortical electrode arrays in dorsal precentral gyrus. biorXiv. pdf url


2. Rastogi A, Willett FR, Abreu J, Crowder DC, Murphy B, Memberg WD, Vargas-Irwin CE, Miller JP, Sweet J, Walter BL, Rezaii PG, Stavisky SD, Hochberg LR, Shenoy KV, Henderson JM, Kirsch RF, Bolu Ajiboye A (2020) The neural representation of force across grasp types in motor cortex of humans with tetraplegia. biorXiv. url
1. Simeral JD, Hosman T, Saab J, Flesher SN, Vilela M, Franco B, Kelemen J, Brandman DM, Ciancibello JG, Rezaii PG, Rosler DM, Shenoy KV**, Henderson JM**, Nurmikko AV, Hochberg LR (2019) Home use of a wireless intracortical brain-computer interface by individuals with tetraplegia. MedrXiv. doi: https://doi.org/10.1101/2019.12.27.19015727 url
Journal papers (peer reviewed)
23. Even-Chen* N,  Muratore* DG, Stavisky SD, Hochberg LR, Henderson JM, Murmann** B, Shenoy** KV (2020) Intracortical neural interface design opportunities for an order of magnitude power saving. Nature Biomedical Engineering. pdf supp_mats url
22. Willett FR*, Deo DR*, Avansino DT, Rezaii Paymon, Hochberg LR, Henderson JM**, Shenoy KV** (2020) Hand knob area of motor cortex in people with tetraplegia represents the whole body in a compositional way. Cell. 181:396–409. pdf url
21. Stavisky SD, Willett FR, Avansino DT, Hochberg LR, Shenoy KV**, Henderson JM** (2020) Speech-related dorsal motor cortex activity does not interfere with iBCI cursor control. Journal of Neural Engineering. 17:016049 (13pp). pdf url
20. Rastogi A, Vargas-Irwin C, Willett F, Abreu J, Crowder DC, Murphy B, Memberg W, Miller J, Sweet J, Walter B, Cash S, Rezaii P, Franco B, Saab J, Stavisky SD, Shenoy KV**, Henderson J**, Hochberg LR, Kirsch R, Ajiboye AB (2020) Neural representation of observed, imagined, and attempted grasping force in motor cortex of individuals with chronic tetraplegia. Scientific Reports. 10:1429. pdf url
19. Stavisky SD,  Willett FR, Wilson GH, Murphy BA, Rezaii P, Avansino D, Memberg WD, Miller JP, Kirsch RF, Hochberg LR, Ajiboye AB, Druckmann S, Shenoy KV**, Henderson JM** (2019) Neural ensemble dynamics in dorsal motor cortex during speech in people with paralysis. eLife. 8:e46015. pdf figure-supplements url
18. Willett FR, Young DR, Murphy BA, Memberg WD, Blabe CH, Pandarinath C, Stavisky SD, Rezaii P, Saab J, Walter BL, Sweet JA, Miller JP, Henderson JM, Shenoy KV, Simeral J, Jarosiewicz B, Hochberg LR, Kirsch RF, Ajiboye AB (2019) Principled BCI decoder design and parameter selection using a feedback control model. Scientific Reports. 9(1):8881. pdf supp mats url
17. Milekovic T, Bacher D, Sarma A, Simeral J, Saab J, Pandarinath C, Yvert B, Sorice B, Blabe C, Oakley E, Tringale K, Eskandar E, Cash S, Shenoy KV, Henderson JM, Hochberg LR, Donoghue JP (2019) Volitional control of single-electrode high gamma local field potentials (LFPs) by people with paralysis. Journal of Neurophysiology. 121:1428-1450. pdf url
16. Young D, Willett F, Memberg W, Murphy B, Rezaii P, Walter B, Sweet J, Miller J, Shenoy KV, Hochberg LR, Kirsch R, Ajiboye AB (2019) Closed-loop cortical control of virtual reach and posture using cartesian and joint velocity commands. Journal of Neural Engineering. 16:026011 (14pp). pdf url
15. Nuyujukian P*, Sanabria JA*, Saab J*, Pandarinath C, Jarosiewicz B, Blabe C, Franco B, Mernoff ST, Eskandar EN, Simeral JD, Hochberg LR**, Shenoy KV**, Henderson JM** (2018) Cortical control of a tablet computer by people with paralysis. PLoS One. 13:e0204566 pdf url-with-all-movies

14. Stavisky SD, Kao JC, Nuyujukian P, Pandarinath C, Blabe C, Ryu SI, Hochberg LR, Henderson JM, Shenoy KV (2018) Brain-machine interface cursor position only weakly affects monkey and human motor cortical activity in the absence of arm movements. Scientific Reports. 8:1635.7 pd


13. Pandarinath C, O'Shea DJ, Collins J, Jozefowicz R, Stavisky SD, Kao JC, Trautmann EM, Kaufman MT, Ryu SI, Hochberg LR, Henderson JM, Shenoy KV, Abbott LF, Sussillo D (2018) Inferring single-trial neural population dynamics using sequential auto-encoders. Nature Methods.15:805-815. pdf url (Also: ​Batista AP, DiCarlo JJ (2018) Deep learning reaches the motor system. Nature Methods. News & Views. 15:772-773. pdf   and   Seminar talk on LFADS by David Sussillo, Simons Institute for the Theory of Computing meeting, UC Berkeley, 3/22/18. video)


12. Milekovic T, Sarma A, Bacher D, Simeral J, Saab J, Pandarinath C, Sorice B, Blabe C, Oakley E, Tringale K, Eskandar E, Cash S, Henderson JM, Shenoy KV, Donoghue JP, Hochberg LR (2018) Stable long-term BCI-enabled communication in ALS and locked-in syndrome using LFP signals. Journal of Neurophysiology. 120:343-360. pdf url


11. Willett FR, Murphy BA, Young D, Memberg WD, Blabe CH, Pandarinath C, Franco B, Saab J, Walter BL, Sweet JA, Miller JP, Henderson JM, Shenoy KV, Simeral JD, Jarosiewicz B, Hochberg LR, Kirsch RF, Ajiboye AB (2018) A comparison of intention estimation methods for decoder calibration in intracortical brain-computer interfaces. IEEE Transactions in Biomedical Engineering. 65:2066-2078. pdf url


10. Even-Chen N, Stavisky SD, Pandarinath C, Nuyujukian P, Blabe CH, Hochberg LR, Henderson* JM, Shenoy* KV (2018) Feasibility of automatic error detect-and-undo system in human intracortical brain-computer interfaces. IEEE Transactions in Biomedical Engineering. 65:1771-1784. pdf url


9. Brandman D, Hosman T, Saab J, Burkhart M, Shanahan B, Ciancibello J, Sarma A, Milstein D, Vargas-Irwin C, Franco B, Kelemen J, Blabe C, Murphy B, Young D, Willett F, Pandarinath C, Stavisky S, Kirsch R, Walter B, Ajiboye A, Cash S, Eskandar E, Miller J, Sweet J, Shenoy KV, Henderson JM, Jarosiewicz B, 9. Harrison M, Simeral J, Hochberg, LR (2018) Rapid calibration of an intracortical brain computer interface for people with tetraplegia. Journal of Neural Engineering. 15:026007. pdf url


8. Pandarinath C*, Nuyujukian P*, Blabe CH, Sorice B, Saab J, Willett F, Hochberg LR, Shenoy KV**, Henderson JM** (2017) High performance communication by people with paralysis using an intracortical brain-computer interface. eLife. 6:e18554 pdf url-with-all-movies


7. Willett FR, Murphy B, Memberg W, Blabe C, Pandarinath C, Walter B, Sweet J, Miller J, Henderson JM, Shenoy KV, Hochberg LR, Kirsch R, Ajiboye AB (2017) Signal-independent noise in intracortical brain-computer interfaces causes movement time properties inconsistent with Fitts' law. Journal of Neural Engineering 14:026010. pdf


6. Willett F, Pandarinath C, Jarosiewicz B, Murphy B, Memberg W, Blabe C, Saab J, Walter B, Sweet J, Miller J, Henderson J, Shenoy KV, Simeral J, Hochberg LR, Kirsch R, Ajiboye AB. (2017) Feedback control policies employed by people using intracortical brain-computer interfaces. Journal of Neural Engineering 14:016001 (16pp). pdf


5. Jarosiewicz B, Sarma AA, Bacher D, Masse NY, Simeral JD, Sorice B, Oakley EM, Blabe C, Pandarinath C, Gilja V, Cash SS, Eskandar E, Friehs G, Henderson JM, Shenoy KV, Donoghue JP, Hochberg LR (2015) Virtual typing by people with tetraplegia using a self-calibrating intracortical brain-computer interface. Science Translational Medicine 7:1-10. pdf supplement video1


4. Gilja V*, Pandarinath C*, Blabe CH, Nuyujukian P, Simeral JD, Sarma AA, Sorice BL, Perge JA, Jarosiewicz B, Hochberg LR, Shenoy KV**, Henderson JM** (2015) Clinical translation of a high performance neural prosthesis. Nature Medicine 21:1142-1145. pdf supplement video1 video2 video3


3. Blabe C, Gilja V, Chestek CA, Shenoy KV, Anderson K, Henderson JM (2015) Assessment of brain-machine interfaces from the perspective of people with paralysis. Journal of Neural Engineering 12:043002. pdf


2. Pandarinath C, Gilja V, Blabe CH, Nuyujukian P, Sarma AA, Sorice BL, Eskandar EN, Hochberg LR, Henderson JM*, Shenoy KV* (2015) Neural population dynamics in human motor cortex during movements in people with ALS. eLife 4:e07436. pdf video1


1. Chestek CA, Gilja V, Blabe CH, Foster BL, Shenoy KV, Parvizi J, Henderson JM (2013) Hand posture classification using electrocorticography signals in the gamma band over human sensorimotor brain areas. Journal of Neural Engineering10:02602 (11pp). pdf

Recent conference papers and abstracts (other than 1 paragraph Soc. for Neurosci. abstracts)

5. Willett FR, Avansino DT, Hochberg LR, Henderson JM**, Shenoy KV** (2020) High-performance brain-to-text communication via imagined handwriting. 1st BCI Un-Conference, Session 3: Language-based BCI-Communication. Talk 8. 12 July 2020. Video starts at 0min 15sec: url-with-video video.mp4

  • Abstract: To date, a major focus of BCI research has been on restoring gross motor skills, such as reaching and grasping or point-and-click typing with a 2D computer cursor. However, rapid sequences of highly dexterous behaviors, such as handwriting or touch typing, might enable faster communication rates. Here, we demonstrate an intracortical BCI that can decode imagined handwriting movements from neural activity in motor cortex and translate it to text in real-time, using a novel recurrent neural network decoding approach. With this BCI, our study participant (whose hand was paralyzed) achieved typing speeds that exceed those of any other BCI yet reported: 90 characters per minute at >99% accuracy with a general-purpose autocorrect. These speeds are comparable to able-bodied smartphone typing speeds in our participant’s age group (115 characters per minute) and significantly close the gap between BCI-enabled typing and able-bodied typing rates. Finally, new theoretical considerations explain why temporally complex movements, such as handwriting, may be fundamentally easier to decode than point-to-point movements. Our results open a new approach for BCIs and demonstrate the feasibility of accurately decoding rapid, dexterous movements years after paralysis.

4. Stavisky SD*, Wilson GH*, Willett FR, Avansino DT, Kelemen JN, Hochberg LR, Henderson JM**, Druckmann S,** Shenoy KV** (2020) Decoding speech production using intracortical electrode arrays in dorsal precentral gyrus. 1st BCI Un-Conference, Session 3: Language-based BCI-Communication, Talk 9. 12 July 2020. Video starts at 19 min 42 sec: url-with-video video.mp4

  • Abstract: Efforts to build brain-computer interfaces (BCIs) to restore lost speech have rapidly accelerated in recent years, with a number of impressive demonstrations using electrocorticography (ECoG). In parallel, BCIs that decode attempted arm and hand movements for controlling a robotic arm and point-and-click typing communication have had the highest performance to date using intracortical electrode arrays. We believe that an intracortical approach is equally promising for speech BCIs and can complement ECoG recordings. However, progress has been slower in this domain due to limited animal models for speech, leading to the need for preliminary work to be done in humans. We have recently made progress prototyping an intracortical speech BCI thanks to our discovery that individual neurons in the dorsal “hand knob” area of the precentral gyrus are active during speech (Stavisky et al., 2019, 2020). Here, we recorded from a BrainGate2 pilot clinical trial participant, who has tetraplegia but can speak, as he spoke visually prompted words that broadly sample a comprehensive set of 39 English phonemes. Phoneme identities could be classified from the neural activity recorded by two 96-electrode arrays with 33.9% accuracy using a recurrent neural network decoder. Performance did not saturate with increasing training data quantity or electrode count. By demonstrating offline performance comparable to previous ECoG studies – despite these arrays being in an area that is very likely suboptimal for speech decoding – these results help lay the groundwork for a concerted speech BCI effort using intracortical measurements from more ventral cortical areas which we expect to have stronger speech-related modulation.

3. Wilson G*, Stavisky SD*, Avansino D, Hochberg LR, Henderson JM**, Shenoy KV**, Druckmann S** (2020) Neural state space geometry in human motor cortex underlying speaking different phonemes. Frontiers in Neuroscience. Conference Abstract: Computational and Systems Neuroscience (COSYNE), Denver, CO. Poster number III-71. pdf


2. Willett F, Avansino D, Hochberg LR, Henderson JM**, Shenoy KV** (2020) Motor Cortical Representation and Decoding of Attempted Handwriting in a Person with Tetraplegia. Frontiers in Neuroscience. Conference Abstract: Computational and Systems Neuroscience (COSYNE), Denver, CO. Poster number III-1. pdf
1. Stavisky SD, Rezaii P, Willett FR, Hochberg LR, Shenoy KV*, Henderson JM* (2018) Decoding speech from intracortical multielectrode arrays in dorsal "arm / hand areas" of human motor cortex. 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Honolulu, HI: 93-97. pdf

 

Last modified: 
Friday, September 11, 2020 - 21:59